PPP1R12C-KISS1 Fusion FISH Probe
The PPP1R12C-KISS1 Fusion FISH Probe is used to confirm a fusion of the PPP1R12C and KISS1 genes. The fusion of the PPP1R12C and KISS1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R12C-KISS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R12C-KISS1-20-AQAQ | 20 (40 μL) | 200 μL |
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KISS1 Gene Summary
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
Gene Name: KiSS-1 Metastasis-suppressor
Chromosome: CHR1: 204159468 -204165619
Locus: 1q32.1
PPP1R12C Gene Summary
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12C
Chromosome: CHR19: 55602280 -55628927
Locus: 19q13.42
Gene Diseases
The PPP1R12C KISS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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