PPP1R12A-DNAH10 Fusion FISH Probe
The PPP1R12A-DNAH10 Fusion FISH Probe is used to confirm a fusion of the PPP1R12A and DNAH10 genes. The fusion of the PPP1R12A and DNAH10 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R12A-DNAH10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R12A-DNAH10-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1R12A Gene Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12A
Chromosome: CHR12: 80167342 -80329235
Locus: 12q21.2-q21.31
DNAH10 Gene Summary
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Gene Name: Dynein Axonemal Heavy Chain 10
Chromosome: CHR12: 124247041 -124420267
Locus: 12q24.31
Gene Diseases
The PPP1R12A DNAH10 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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