PPP1R10-MUS81 Fusion FISH Probe
The PPP1R10-MUS81 Fusion FISH Probe is used to confirm a fusion of the PPP1R10 and MUS81 genes. The fusion of the PPP1R10 and MUS81 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1R10-MUS81-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1R10-MUS81-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1R10 Gene Summary
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 10
Chromosome: CHR6_mcf_hap5: 1950036 -1966876
Locus: 6p21.33
MUS81 Gene Summary
This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]
Gene Name: MUS81 Structure-specific Endonuclease Subunit
Chromosome: CHR11: 65627871 -65633914
Locus: 11q13.1
Gene Diseases
The PPP1R10 MUS81 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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