PPP1CB-PLB1 Fusion FISH Probe
The PPP1CB-PLB1 Fusion FISH Probe is used to confirm a fusion of the PPP1CB and PLB1 genes. The fusion of the PPP1CB and PLB1 genes has been associated with Ovarian Serous Cystadenocarcinoma, Breast Invasive Carcinoma, Stomach Adenocarcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1CB-PLB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1CB-PLB1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1CB Gene Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Catalytic Subunit Beta
Chromosome: CHR2: 28974613 -29025806
Locus: 2p23.2
PLB1 Gene Summary
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
Gene Name: Phospholipase B1
Chromosome: CHR2: 28718937 -28866653
Locus: 2p23.2
Gene Diseases
The PPP1CB PLB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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