PPP1CB-CCT5 Fusion FISH Probe
The PPP1CB-CCT5 Fusion FISH Probe is used to confirm a fusion of the PPP1CB and CCT5 genes. The fusion of the PPP1CB and CCT5 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPP1CB-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| PPP1CB-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1CB Gene Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Catalytic Subunit Beta
Chromosome: CHR2: 28974613 -29025806
Locus: 2p23.2
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The PPP1CB CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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