PPM1H-DYRK2 Fusion FISH Probe
The PPM1H-DYRK2 Fusion FISH Probe is used to confirm a fusion of the PPM1H and DYRK2 genes. The fusion of the PPM1H and DYRK2 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPM1H-DYRK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-RERE | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-REOR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-REGO | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-REGR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-REAQ | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-ORRE | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-OROR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-ORGO | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GORE | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GOOR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GOGO | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GOGR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GRRE | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GROR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GRGO | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GRGR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-AQRE | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-AQOR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-AQGO | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-AQGR | 20 (40 μL) | 200 μL |
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| PPM1H-DYRK2-20-AQAQ | 20 (40 μL) | 200 μL |
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DYRK2 Gene Summary
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Gene Name: Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2
Chromosome: CHR12: 68042511 -68056444
Locus: 12q15
PPM1H Gene Summary
The Protein Phosphatase, Mg2+/Mn2+ Dependent 1H (PPM1H) gene is located on chr12 :63037762-63328665 at 12q14.1-q14.2.
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1H
Chromosome: CHR12: 63037762 -63328665
Locus: 12q14.1-q14.2
Gene Diseases
The PPM1H DYRK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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