PPM1G-KATNA1 Fusion FISH Probe
The PPM1G-KATNA1 Fusion FISH Probe is used to confirm a fusion of the PPM1G and KATNA1 genes. The fusion of the PPM1G and KATNA1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPM1G-KATNA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-RERE | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-REOR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-REGO | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-REGR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-OROR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GORE | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GROR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPM1G-KATNA1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPM1G Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1G
Chromosome: CHR2: 27604060 -27632496
Locus: 2p23.3
KATNA1 Gene Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Gene Name: Katanin Catalytic Subunit A1
Chromosome: CHR6: 149916010 -149969940
Locus: 6q25.1
Gene Diseases
The PPM1G KATNA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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