PPM1D-NUP85 Fusion FISH Probe
The PPM1D-NUP85 Fusion FISH Probe is used to confirm a fusion of the PPM1D and NUP85 genes. The fusion of the PPM1D and NUP85 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPM1D-NUP85-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-RERE | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-REOR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-REGO | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-REGR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-REAQ | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-ORRE | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-OROR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-ORGO | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GORE | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GOOR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GOGO | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GOGR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GRRE | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GROR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GRGO | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GRGR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-AQRE | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-AQOR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-AQGO | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-AQGR | 20 (40 μL) | 200 μL |
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| PPM1D-NUP85-20-AQAQ | 20 (40 μL) | 200 μL |
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PPM1D Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1D
Chromosome: CHR17: 58677543 -58743640
Locus: 17q23.2
NUP85 Gene Summary
This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Nucleoporin 85
Chromosome: CHR17: 73201596 -73231854
Locus: 17q25.1
Gene Diseases
The PPM1D NUP85 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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