PPM1B-SRBD1 Fusion FISH Probe
The PPM1B-SRBD1 Fusion FISH Probe is used to confirm a fusion of the PPM1B and SRBD1 genes. The fusion of the PPM1B and SRBD1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPM1B-SRBD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-RERE | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-REOR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-REGO | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-REGR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-OROR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GORE | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GROR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPM1B-SRBD1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPM1B Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1B
Chromosome: CHR2: 44395999 -44461742
Locus: 2p21
SRBD1 Gene Summary
The S1 RNA Binding Domain 1 (SRBD1) gene is located on chr2 :45615818-45838433 at 2p21.
Gene Name: S1 RNA Binding Domain 1
Chromosome: CHR2: 45615818 -45838433
Locus: 2p21
Gene Diseases
The PPM1B SRBD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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