PPM1A-ADCK4 Fusion FISH Probe
The PPM1A-ADCK4 Fusion FISH Probe is used to confirm a fusion of the PPM1A and ADCK4 genes. The fusion of the PPM1A and ADCK4 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPM1A-ADCK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-RERE | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-REOR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-REGO | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-REGR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-REAQ | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-ORRE | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-OROR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-ORGO | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GORE | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GOOR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GOGO | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GOGR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GRRE | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GROR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GRGO | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GRGR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-AQRE | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-AQOR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-AQGO | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-AQGR | 20 (40 μL) | 200 μL |
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| PPM1A-ADCK4-20-AQAQ | 20 (40 μL) | 200 μL |
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PPM1A Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1A
Chromosome: CHR14: 60712469 -60765805
Locus: 14q23.1
Gene Diseases
The PPM1A ADCK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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