PPL-APOL3 Fusion FISH Probe
The PPL-APOL3 Fusion FISH Probe is used to confirm a fusion of the PPL and APOL3 genes. The fusion of the PPL and APOL3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPL-APOL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-RERE | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-REOR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-REGO | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-REGR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-REAQ | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-ORRE | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-OROR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-ORGO | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GORE | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GOOR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GOGO | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GOGR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GRRE | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GROR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GRGO | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GRGR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-AQRE | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-AQOR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-AQGO | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-AQGR | 20 (40 μL) | 200 μL |
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| PPL-APOL3-20-AQAQ | 20 (40 μL) | 200 μL |
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PPL Gene Summary
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Gene Name: Periplakin
Chromosome: CHR16: 4932507 -4987136
Locus: 16p13.3
APOL3 Gene Summary
This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Gene Name: Apolipoprotein L3
Chromosome: CHR22: 36536370 -36562225
Locus: 22q12.3
Gene Diseases
The PPL APOL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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