PPIP5K2-PRODH Fusion FISH Probe
The PPIP5K2-PRODH Fusion FISH Probe is used to confirm a fusion of the PPIP5K2 and PRODH genes. The fusion of the PPIP5K2 and PRODH genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPIP5K2-PRODH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-RERE | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-REOR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-REGO | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-REGR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-REAQ | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-ORRE | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-OROR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-ORGO | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GORE | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GOOR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GOGO | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GOGR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GRRE | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GROR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GRGO | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GRGR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-AQRE | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-AQOR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-AQGO | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-AQGR | 20 (40 μL) | 200 μL |
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| PPIP5K2-PRODH-20-AQAQ | 20 (40 μL) | 200 μL |
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PRODH Gene Summary
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Name: Proline Dehydrogenase 1
Chromosome: CHR22: 18900286 -18924066
Locus: 22q11.21
PPIP5K2 Gene Summary
This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016]
Gene Name: Diphosphoinositol Pentakisphosphate Kinase 2
Chromosome: CHR5: 102465256 -102538909
Locus: 5q21.1
Gene Diseases
The PPIP5K2 PRODH Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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