PPIL2-TBX1 Fusion FISH Probe
The PPIL2-TBX1 Fusion FISH Probe is used to confirm a fusion of the PPIL2 and TBX1 genes. The fusion of the PPIL2 and TBX1 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPIL2-TBX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-RERE | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-REOR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-REGO | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-REGR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-OROR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GORE | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GROR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPIL2-TBX1-20-AQAQ | 20 (40 μL) | 200 μL |
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TBX1 Gene Summary
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: T-box 1
Chromosome: CHR22: 19744225 -19771112
Locus: 22q11.21
PPIL2 Gene Summary
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: Peptidylprolyl Isomerase Like 2
Chromosome: CHR22: 22020272 -22052202
Locus: 22q11.21
Gene Diseases
The PPIL2 TBX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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