PPHLN1-TIMELESS Fusion FISH Probe
The PPHLN1-TIMELESS Fusion FISH Probe is used to confirm a fusion of the PPHLN1 and TIMELESS genes. The fusion of the PPHLN1 and TIMELESS genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPHLN1-TIMELESS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-RERE | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-REOR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-REGO | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-REGR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-REAQ | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-ORRE | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-OROR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-ORGO | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GORE | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GOOR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GOGO | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GOGR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GRRE | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GROR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GRGO | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GRGR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-AQRE | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-AQOR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-AQGO | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-AQGR | 20 (40 μL) | 200 μL |
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| PPHLN1-TIMELESS-20-AQAQ | 20 (40 μL) | 200 μL |
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TIMELESS Gene Summary
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
Gene Name: Timeless Circadian Regulator
Chromosome: CHR12: 56810156 -56843200
Locus: 12q13.3
PPHLN1 Gene Summary
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Periphilin 1
Chromosome: CHR12: 42719946 -42842422
Locus: 12q12
Gene Diseases
The PPHLN1 TIMELESS Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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