PPFIBP1-SLCO1B1 Fusion FISH Probe
The PPFIBP1-SLCO1B1 Fusion FISH Probe is used to confirm a fusion of the PPFIBP1 and SLCO1B1 genes. The fusion of the PPFIBP1 and SLCO1B1 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIBP1-SLCO1B1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-SLCO1B1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPFIBP1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PPFIA Binding Protein 1
Chromosome: CHR12: 27677044 -27848497
Locus: 12p11.23-p11.22
SLCO1B1 Gene Summary
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
Gene Name: Solute Carrier Organic Anion Transporter Family Member 1B1
Chromosome: CHR12: 21284127 -21392730
Locus: 12p12.1
Gene Diseases
The PPFIBP1 SLCO1B1 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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