PPFIBP1-ADIPOR2 Fusion FISH Probe
The PPFIBP1-ADIPOR2 Fusion FISH Probe is used to confirm a fusion of the PPFIBP1 and ADIPOR2 genes. The fusion of the PPFIBP1 and ADIPOR2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIBP1-ADIPOR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIBP1-ADIPOR2-20-AQAQ | 20 (40 μL) | 200 μL |
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PPFIBP1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PPFIA Binding Protein 1
Chromosome: CHR12: 27677044 -27848497
Locus: 12p11.23-p11.22
ADIPOR2 Gene Summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Gene Name: Adiponectin Receptor 2
Chromosome: CHR12: 1800246 -1897845
Locus: 12p13.33
Gene Diseases
The PPFIBP1 ADIPOR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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