PPFIA1-SRD5A3 Fusion FISH Probe
The PPFIA1-SRD5A3 Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and SRD5A3 genes. The fusion of the PPFIA1 and SRD5A3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIA1-SRD5A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIA1-SRD5A3-20-AQAQ | 20 (40 μL) | 200 μL |
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PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
SRD5A3 Gene Summary
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
Gene Name: Steroid 5 Alpha-reductase 3
Chromosome: CHR4: 56212387 -56239266
Locus: 4q12
Gene Diseases
The PPFIA1 SRD5A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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