PPFIA1-MARK2 Fusion FISH Probe
The PPFIA1-MARK2 Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and MARK2 genes. The fusion of the PPFIA1 and MARK2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIA1-MARK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIA1-MARK2-20-AQAQ | 20 (40 μL) | 200 μL |
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MARK2 Gene Summary
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Name: Microtubule Affinity Regulating Kinase 2
Chromosome: CHR11: 63606399 -63678492
Locus: 11q13.1
PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
Gene Diseases
The PPFIA1 MARK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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