PPFIA1-HSD3B2 Fusion FISH Probe
The PPFIA1-HSD3B2 Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and HSD3B2 genes. The fusion of the PPFIA1 and HSD3B2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIA1-HSD3B2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIA1-HSD3B2-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD3B2 Gene Summary
The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Hydroxy-delta-5-steroid Dehydrogenase, 3 Beta- And Steroid Delta-isomerase 2
Chromosome: CHR1: 119957553 -119965662
Locus: 1p12
PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
Gene Diseases
The PPFIA1 HSD3B2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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