PPFIA1-CBLB Fusion FISH Probe
The PPFIA1-CBLB Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and CBLB genes. The fusion of the PPFIA1 and CBLB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIA1-CBLB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIA1-CBLB-20-AQAQ | 20 (40 μL) | 200 μL |
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CBLB Gene Summary
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Gene Name: Cbl Proto-oncogene B
Chromosome: CHR3: 105377108 -105587887
Locus: 3q13.11
PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
Gene Diseases
The PPFIA1 CBLB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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