PPFIA1-BBOX1 Fusion FISH Probe
The PPFIA1-BBOX1 Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and BBOX1 genes. The fusion of the PPFIA1 and BBOX1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPFIA1-BBOX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-RERE | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-REOR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-REGO | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-REGR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-OROR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GORE | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GROR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPFIA1-BBOX1-20-AQAQ | 20 (40 μL) | 200 μL |
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BBOX1 Gene Summary
This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008]
Gene Name: Gamma-butyrobetaine Hydroxylase 1
Chromosome: CHR11: 27062508 -27149354
Locus: 11p14.2
PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
Gene Diseases
The PPFIA1 BBOX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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