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PPFIA1-BBOX1 Fusion FISH Probe

The PPFIA1-BBOX1 Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and BBOX1 genes. The fusion of the PPFIA1 and BBOX1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PPFIA1-BBOX1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-RERE 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-REOR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-REGO 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-REGR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-REAQ 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-ORRE 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-OROR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-ORGO 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-ORAQ 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GORE 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GOOR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GOGO 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GOGR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GOAQ 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GRRE 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GROR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GRGO 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GRGR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-GRAQ 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-AQRE 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-AQOR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-AQGO 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-AQGR 20 (40 μL) 200 μL
PPFIA1-BBOX1-20-AQAQ 20 (40 μL) 200 μL

BBOX1 Gene Summary

This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008]

Gene Name: Gamma-butyrobetaine Hydroxylase 1

Chromosome: CHR11: 27062508 -27149354

Locus: 11p14.2

PPFIA1 Gene Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Name: PTPRF Interacting Protein Alpha 1

Chromosome: CHR11: 70116822 -70230502

Locus: 11q13.3

Gene Diseases

The PPFIA1 BBOX1 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.