PPARA-FBLN1 Fusion FISH Probe
The PPARA-FBLN1 Fusion FISH Probe is used to confirm a fusion of the PPARA and FBLN1 genes. The fusion of the PPARA and FBLN1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPARA-FBLN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-RERE | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-REOR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-REGO | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-REGR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-REAQ | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-ORRE | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-OROR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-ORGO | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GORE | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GOOR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GOGO | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GOGR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GRRE | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GROR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GRGO | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GRGR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-AQRE | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-AQOR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-AQGO | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-AQGR | 20 (40 μL) | 200 μL |
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| PPARA-FBLN1-20-AQAQ | 20 (40 μL) | 200 μL |
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FBLN1 Gene Summary
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
Gene Name: Fibulin 1
Chromosome: CHR22: 45898718 -45997014
Locus: 22q13.31
PPARA Gene Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Gene Name: Peroxisome Proliferator Activated Receptor Alpha
Chromosome: CHR22: 46546498 -46639653
Locus: 22q13.31
Gene Diseases
The PPARA FBLN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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