PPARA-BCL2L13 Fusion FISH Probe
The PPARA-BCL2L13 Fusion FISH Probe is used to confirm a fusion of the PPARA and BCL2L13 genes. The fusion of the PPARA and BCL2L13 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PPARA-BCL2L13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-RERE | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-REOR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-REGO | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-REGR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-REAQ | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-ORRE | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-OROR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-ORGO | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-ORAQ | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GORE | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GOOR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GOGO | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GOGR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GOAQ | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GRRE | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GROR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GRGO | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GRGR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-GRAQ | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-AQRE | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-AQOR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-AQGO | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-AQGR | 20 (40 μL) | 200 μL |
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| PPARA-BCL2L13-20-AQAQ | 20 (40 μL) | 200 μL |
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PPARA Gene Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Gene Name: Peroxisome Proliferator Activated Receptor Alpha
Chromosome: CHR22: 46546498 -46639653
Locus: 22q13.31
BCL2L13 Gene Summary
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: BCL2 Like 13
Chromosome: CHR22: 18121484 -18211989
Locus: 22q11.21
Gene Diseases
The PPARA BCL2L13 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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