POU2F1-FMO1 Fusion FISH Probe
The POU2F1-FMO1 Fusion FISH Probe is used to confirm a fusion of the POU2F1 and FMO1 genes. The fusion of the POU2F1 and FMO1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POU2F1-FMO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-RERE | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-REOR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-REGO | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-REGR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-REAQ | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-ORRE | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-OROR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-ORGO | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GORE | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GOOR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GOGO | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GOGR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GRRE | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GROR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GRGO | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GRGR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-AQRE | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-AQOR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-AQGO | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-AQGR | 20 (40 μL) | 200 μL |
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| POU2F1-FMO1-20-AQAQ | 20 (40 μL) | 200 μL |
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FMO1 Gene Summary
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Flavin Containing Monooxygenase 1
Chromosome: CHR1: 171217662 -171255113
Locus: 1q24.3
POU2F1 Gene Summary
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
Gene Name: POU Class 2 Homeobox 1
Chromosome: CHR1: 167190065 -167396582
Locus: 1q24.2
Gene Diseases
The POU2F1 FMO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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