POLR3B-RBM19 Fusion FISH Probe
The POLR3B-RBM19 Fusion FISH Probe is used to confirm a fusion of the POLR3B and RBM19 genes. The fusion of the POLR3B and RBM19 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR3B-RBM19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-RERE | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-REOR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-REGO | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-REGR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-OROR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GORE | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GROR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR3B-RBM19-20-AQAQ | 20 (40 μL) | 200 μL |
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RBM19 Gene Summary
This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]
Gene Name: RNA Binding Motif Protein 19
Chromosome: CHR12: 114254542 -114404176
Locus: 12q24.13-q24.21
POLR3B Gene Summary
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: RNA Polymerase III Subunit B
Chromosome: CHR12: 106751435 -106903976
Locus: 12q23.3
Gene Diseases
The POLR3B RBM19 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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