POLR2B-FIP1L1 Fusion FISH Probe
The POLR2B-FIP1L1 Fusion FISH Probe is used to confirm a fusion of the POLR2B and FIP1L1 genes. The fusion of the POLR2B and FIP1L1 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR2B-FIP1L1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-RERE | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-REOR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-REGO | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-REGR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-OROR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GORE | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GROR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR2B-FIP1L1-20-AQAQ | 20 (40 μL) | 200 μL |
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POLR2B Gene Summary
This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: RNA Polymerase II Subunit B
Chromosome: CHR4: 57845108 -57897334
Locus: 4q12
FIP1L1 Gene Summary
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Factor Interacting With PAPOLA And CPSF1
Chromosome: CHR4: 54243819 -54326103
Locus: 4q12
Gene Diseases
The POLR2B FIP1L1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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