POLR2B-CEP135 Fusion FISH Probe
The POLR2B-CEP135 Fusion FISH Probe is used to confirm a fusion of the POLR2B and CEP135 genes. The fusion of the POLR2B and CEP135 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR2B-CEP135-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-RERE | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-REOR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-REGO | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-REGR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-OROR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GORE | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GROR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR2B-CEP135-20-AQAQ | 20 (40 μL) | 200 μL |
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POLR2B Gene Summary
This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: RNA Polymerase II Subunit B
Chromosome: CHR4: 57845108 -57897334
Locus: 4q12
CEP135 Gene Summary
This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012]
Gene Name: Centrosomal Protein 135
Chromosome: CHR4: 56815036 -56899527
Locus: 4q12
Gene Diseases
The POLR2B CEP135 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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