POLG-CGNL1 Fusion FISH Probe
The POLG-CGNL1 Fusion FISH Probe is used to confirm a fusion of the POLG and CGNL1 genes. The fusion of the POLG and CGNL1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLG-CGNL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-RERE | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-REOR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-REGO | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-REGR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-REAQ | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-ORRE | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-OROR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-ORGO | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GORE | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GOOR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GOGO | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GOGR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GRRE | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GROR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GRGO | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GRGR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-AQRE | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-AQOR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-AQGO | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-AQGR | 20 (40 μL) | 200 μL |
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| POLG-CGNL1-20-AQAQ | 20 (40 μL) | 200 μL |
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POLG Gene Summary
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: DNA Polymerase Gamma, Catalytic Subunit
Chromosome: CHR15: 89859535 -89878026
Locus: 15q26.1
CGNL1 Gene Summary
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Cingulin Like 1
Chromosome: CHR15: 57668704 -57842921
Locus: 15q21.3
Gene Diseases
The POLG CGNL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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