POLD3-PPME1 Fusion FISH Probe
The POLD3-PPME1 Fusion FISH Probe is used to confirm a fusion of the POLD3 and PPME1 genes. The fusion of the POLD3 and PPME1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLD3-PPME1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-RERE | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-REOR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-REGO | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-REGR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-REAQ | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-ORRE | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-OROR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-ORGO | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GORE | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GOOR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GOGO | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GOGR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GRRE | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GROR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GRGO | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GRGR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-AQRE | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-AQOR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-AQGO | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-AQGR | 20 (40 μL) | 200 μL |
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| POLD3-PPME1-20-AQAQ | 20 (40 μL) | 200 μL |
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POLD3 Gene Summary
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: DNA Polymerase Delta 3, Accessory Subunit
Chromosome: CHR11: 74303628 -74353765
Locus: 11q13.4
PPME1 Gene Summary
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Name: Protein Phosphatase Methylesterase 1
Chromosome: CHR11: 73882367 -73965748
Locus: 11q13.4
Gene Diseases
The POLD3 PPME1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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