POFUT2-LRP2 Fusion FISH Probe
The POFUT2-LRP2 Fusion FISH Probe is used to confirm a fusion of the POFUT2 and LRP2 genes. The fusion of the POFUT2 and LRP2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POFUT2-LRP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-RERE | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-REOR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-REGO | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-REGR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-REAQ | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-ORRE | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-OROR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-ORGO | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GORE | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GOOR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GOGO | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GOGR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GRRE | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GROR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GRGO | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GRGR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-AQRE | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-AQOR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-AQGO | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-AQGR | 20 (40 μL) | 200 μL |
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| POFUT2-LRP2-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP2 Gene Summary
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Gene Name: LDL Receptor Related Protein 2
Chromosome: CHR2: 169983618 -170219122
Locus: 2q31.1
POFUT2 Gene Summary
Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]).[supplied by OMIM, Mar 2008]
Gene Name: Protein O-fucosyltransferase 2
Chromosome: CHR21: 46683842 -46707811
Locus: 21q22.3
Gene Diseases
The POFUT2 LRP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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