POFUT1-HCK Fusion FISH Probe
The POFUT1-HCK Fusion FISH Probe is used to confirm a fusion of the POFUT1 and HCK genes. The fusion of the POFUT1 and HCK genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POFUT1-HCK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-RERE | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-REOR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-REGO | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-REGR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-REAQ | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-ORRE | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-OROR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-ORGO | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-ORAQ | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GORE | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GOOR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GOGO | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GOGR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GOAQ | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GRRE | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GROR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GRGO | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GRGR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-GRAQ | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-AQRE | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-AQOR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-AQGO | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-AQGR | 20 (40 μL) | 200 μL |
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| POFUT1-HCK-20-AQAQ | 20 (40 μL) | 200 μL |
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HCK Gene Summary
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
Gene Name: HCK Proto-oncogene, Src Family Tyrosine Kinase
Chromosome: CHR20: 30639990 -30689657
Locus: 20q11.21
POFUT1 Gene Summary
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein O-fucosyltransferase 1
Chromosome: CHR20: 30795695 -30826467
Locus: 20q11.21
Gene Diseases
The POFUT1 HCK Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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