POC1B-KRT78 Fusion FISH Probe
The POC1B-KRT78 Fusion FISH Probe is used to confirm a fusion of the POC1B and KRT78 genes. The fusion of the POC1B and KRT78 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| POC1B-KRT78-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-RERE | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-REOR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-REGO | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-REGR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-OROR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GORE | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GROR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| POC1B-KRT78-20-AQAQ | 20 (40 μL) | 200 μL |
|
KRT78 Gene Summary
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Keratin 78
Chromosome: CHR12: 53232745 -53242778
Locus: 12q13.13
POC1B Gene Summary
POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Gene Name: POC1 Centriolar Protein B
Chromosome: CHR12: 89813497 -89920039
Locus: 12q21.33
Gene Diseases
The POC1B KRT78 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|