PMS2-DNAH11 Fusion FISH Probe
The PMS2-DNAH11 Fusion FISH Probe is used to confirm a fusion of the PMS2 and DNAH11 genes. The fusion of the PMS2 and DNAH11 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PMS2-DNAH11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PMS2-DNAH11-20-AQAQ | 20 (40 μL) | 200 μL |
|
PMS2 Gene Summary
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]
Gene Name: PMS1 Homolog 2, Mismatch Repair System Component
Chromosome: CHR7: 6012869 -6048737
Locus: 7p22.1
DNAH11 Gene Summary
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
Gene Name: Dynein Axonemal Heavy Chain 11
Chromosome: CHR7: 21582832 -21941457
Locus: 7p15.3
Gene Diseases
The PMS2 DNAH11 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|