PMS2-AIMP2 Fusion FISH Probe
The PMS2-AIMP2 Fusion FISH Probe is used to confirm a fusion of the PMS2 and AIMP2 genes. The fusion of the PMS2 and AIMP2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PMS2-AIMP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-RERE | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-REOR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-REGO | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-REGR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-REAQ | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-ORRE | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-OROR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-ORGO | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GORE | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GOOR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GOGO | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GOGR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GRRE | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GROR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GRGO | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GRGR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-AQRE | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-AQOR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-AQGO | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-AQGR | 20 (40 μL) | 200 μL |
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| PMS2-AIMP2-20-AQAQ | 20 (40 μL) | 200 μL |
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PMS2 Gene Summary
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]
Gene Name: PMS1 Homolog 2, Mismatch Repair System Component
Chromosome: CHR7: 6012869 -6048737
Locus: 7p22.1
AIMP2 Gene Summary
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Gene Name: Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2
Chromosome: CHR7: 6048881 -6063465
Locus: 7p22.1
Gene Diseases
The PMS2 AIMP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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