PMPCB-WWOX Fusion FISH Probe
The PMPCB-WWOX Fusion FISH Probe is used to confirm a fusion of the PMPCB and WWOX genes. The fusion of the PMPCB and WWOX genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PMPCB-WWOX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-RERE | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-REOR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-REGO | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-REGR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-REAQ | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-ORRE | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-OROR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-ORGO | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-ORAQ | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GORE | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GOOR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GOGO | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GOGR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GOAQ | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GRRE | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GROR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GRGO | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GRGR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-GRAQ | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-AQRE | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-AQOR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-AQGO | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-AQGR | 20 (40 μL) | 200 μL |
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| PMPCB-WWOX-20-AQAQ | 20 (40 μL) | 200 μL |
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PMPCB Gene Summary
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]
Gene Name: Peptidase, Mitochondrial Processing Beta Subunit
Chromosome: CHR7: 102937872 -102955133
Locus: 7q22.1
WWOX Gene Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: WW Domain Containing Oxidoreductase
Chromosome: CHR16: 78133326 -79246564
Locus: 16q23.1-q23.2
Gene Diseases
The PMPCB WWOX Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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