PMPCB-PRKAR2B Fusion FISH Probe
The PMPCB-PRKAR2B Fusion FISH Probe is used to confirm a fusion of the PMPCB and PRKAR2B genes. The fusion of the PMPCB and PRKAR2B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PMPCB-PRKAR2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-RERE | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-REOR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-REGO | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-REGR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-REAQ | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-ORRE | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-OROR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-ORGO | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GORE | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GOOR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GOGO | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GOGR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GRRE | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GROR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GRGO | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GRGR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-AQRE | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-AQOR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-AQGO | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-AQGR | 20 (40 μL) | 200 μL |
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| PMPCB-PRKAR2B-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAR2B Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Beta
Chromosome: CHR7: 106685177 -106802256
Locus: 7q22.3
PMPCB Gene Summary
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]
Gene Name: Peptidase, Mitochondrial Processing Beta Subunit
Chromosome: CHR7: 102937872 -102955133
Locus: 7q22.1
Gene Diseases
The PMPCB PRKAR2B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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