PLXNC1-INSR Fusion FISH Probe
The PLXNC1-INSR Fusion FISH Probe is used to confirm a fusion of the PLXNC1 and INSR genes. The fusion of the PLXNC1 and INSR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLXNC1-INSR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-RERE | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-REOR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-REGO | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-REGR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-REAQ | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-ORRE | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-OROR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-ORGO | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GORE | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GOOR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GOGO | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GOGR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GRRE | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GROR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GRGO | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GRGR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-AQRE | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-AQOR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-AQGO | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-AQGR | 20 (40 μL) | 200 μL |
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| PLXNC1-INSR-20-AQAQ | 20 (40 μL) | 200 μL |
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INSR Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Insulin Receptor
Chromosome: CHR19: 7112265 -7294011
Locus: 19p13.2
PLXNC1 Gene Summary
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Plexin C1
Chromosome: CHR12: 94542498 -94701451
Locus: 12q22
Gene Diseases
The PLXNC1 INSR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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