PLXNA3-TKTL1 Fusion FISH Probe
The PLXNA3-TKTL1 Fusion FISH Probe is used to confirm a fusion of the PLXNA3 and TKTL1 genes. The fusion of the PLXNA3 and TKTL1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLXNA3-TKTL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-RERE | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-REOR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-REGO | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-REGR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-OROR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GORE | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GROR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLXNA3-TKTL1-20-AQAQ | 20 (40 μL) | 200 μL |
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TKTL1 Gene Summary
The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: Transketolase Like 1
Chromosome: CHRX: 153524026 -153558713
Locus: Xq28
PLXNA3 Gene Summary
This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]
Gene Name: Plexin A3
Chromosome: CHRX: 153686622 -153701985
Locus: Xq28
Gene Diseases
The PLXNA3 TKTL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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