PLS1-PIK3CB Fusion FISH Probe
The PLS1-PIK3CB Fusion FISH Probe is used to confirm a fusion of the PLS1 and PIK3CB genes. The fusion of the PLS1 and PIK3CB genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLS1-PIK3CB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-RERE | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-REOR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-REGO | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-REGR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-REAQ | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-ORRE | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-OROR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-ORGO | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GORE | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GOOR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GOGO | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GOGR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GRRE | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GROR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GRGO | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GRGR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-AQRE | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-AQOR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-AQGO | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-AQGR | 20 (40 μL) | 200 μL |
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| PLS1-PIK3CB-20-AQAQ | 20 (40 μL) | 200 μL |
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PIK3CB Gene Summary
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome: CHR3: 138374230 -138478185
Locus: 3q22.3
PLS1 Gene Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Gene Name: Plastin 1
Chromosome: CHR3: 142315228 -142432505
Locus: 3q23
Gene Diseases
The PLS1 PIK3CB Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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