PLOD2-ABCG1 Fusion FISH Probe
The PLOD2-ABCG1 Fusion FISH Probe is used to confirm a fusion of the PLOD2 and ABCG1 genes. The fusion of the PLOD2 and ABCG1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLOD2-ABCG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-RERE | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-REOR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-REGO | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-REGR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-OROR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GORE | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GROR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLOD2-ABCG1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLOD2 Gene Summary
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Chromosome: CHR3: 145787227 -145879282
Locus: 3q24
ABCG1 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
Gene Name: ATP Binding Cassette Subfamily G Member 1
Chromosome: CHR21: 43619798 -43717354
Locus: 21q22.3
Gene Diseases
The PLOD2 ABCG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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