PLEKHM2-IGF2BP2 Fusion FISH Probe
The PLEKHM2-IGF2BP2 Fusion FISH Probe is used to confirm a fusion of the PLEKHM2 and IGF2BP2 genes. The fusion of the PLEKHM2 and IGF2BP2 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLEKHM2-IGF2BP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-RERE | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-REOR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-REGO | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-REGR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-REAQ | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-ORRE | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-OROR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-ORGO | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GORE | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GOOR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GOGO | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GOGR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GRRE | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GROR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GRGO | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GRGR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-AQRE | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-AQOR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-AQGO | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-AQGR | 20 (40 μL) | 200 μL |
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| PLEKHM2-IGF2BP2-20-AQAQ | 20 (40 μL) | 200 μL |
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IGF2BP2 Gene Summary
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Gene Name: Insulin Like Growth Factor 2 MRNA Binding Protein 2
Chromosome: CHR3: 185361526 -185542827
Locus: 3q27.2
PLEKHM2 Gene Summary
This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Gene Name: Pleckstrin Homology And RUN Domain Containing M2
Chromosome: CHR1: 16010826 -16061264
Locus: 1p36.21
Gene Diseases
The PLEKHM2 IGF2BP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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