PLEKHG3-MTHFD1 Fusion FISH Probe
The PLEKHG3-MTHFD1 Fusion FISH Probe is used to confirm a fusion of the PLEKHG3 and MTHFD1 genes. The fusion of the PLEKHG3 and MTHFD1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLEKHG3-MTHFD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-RERE | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-REOR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-REGO | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-REGR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-OROR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GORE | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GROR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLEKHG3-MTHFD1-20-AQAQ | 20 (40 μL) | 200 μL |
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MTHFD1 Gene Summary
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]
Gene Name: Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1
Chromosome: CHR14: 64854758 -64926725
Locus: 14q23.3
PLEKHG3 Gene Summary
The Pleckstrin Homology And RhoGEF Domain Containing G3 (PLEKHG3) gene is located on chr14 :65171192-65211060 at 14q23.3.
Gene Name: Pleckstrin Homology And RhoGEF Domain Containing G3
Chromosome: CHR14: 65171192 -65211060
Locus: 14q23.3
Gene Diseases
The PLEKHG3 MTHFD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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