PLEKHA7-ABCC8 Fusion FISH Probe
The PLEKHA7-ABCC8 Fusion FISH Probe is used to confirm a fusion of the PLEKHA7 and ABCC8 genes. The fusion of the PLEKHA7 and ABCC8 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLEKHA7-ABCC8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-RERE | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-REOR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-REGO | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-REGR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-REAQ | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-ORRE | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-OROR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-ORGO | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GORE | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GOOR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GOGO | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GOGR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GRRE | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GROR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GRGO | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GRGR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-AQRE | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-AQOR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-AQGO | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-AQGR | 20 (40 μL) | 200 μL |
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| PLEKHA7-ABCC8-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCC8 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Name: ATP Binding Cassette Subfamily C Member 8
Chromosome: CHR11: 17414431 -17498449
Locus: 11p15.1
PLEKHA7 Gene Summary
The Pleckstrin Homology Domain Containing A7 (PLEKHA7) gene is located on chr11 :16809206-17035963 at 11p15.2-p15.1.
Gene Name: Pleckstrin Homology Domain Containing A7
Chromosome: CHR11: 16809206 -17035963
Locus: 11p15.2-p15.1
Gene Diseases
The PLEKHA7 ABCC8 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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