PLEKHA5-UHRF1 Fusion FISH Probe
The PLEKHA5-UHRF1 Fusion FISH Probe is used to confirm a fusion of the PLEKHA5 and UHRF1 genes. The fusion of the PLEKHA5 and UHRF1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLEKHA5-UHRF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-RERE | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-REOR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-REGO | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-REGR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-OROR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GORE | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GROR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLEKHA5-UHRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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UHRF1 Gene Summary
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Gene Name: Ubiquitin Like With PHD And Ring Finger Domains 1
Chromosome: CHR19: 4909509 -4962165
Locus: 19p13.3
PLEKHA5 Gene Summary
The Pleckstrin Homology Domain Containing A5 (PLEKHA5) gene is located on chr12 :19282625-19529333 at 12p12.3.
Gene Name: Pleckstrin Homology Domain Containing A5
Chromosome: CHR12: 19282625 -19529333
Locus: 12p12.3
Gene Diseases
The PLEKHA5 UHRF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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