PLCG1-EYA2 Fusion FISH Probe
The PLCG1-EYA2 Fusion FISH Probe is used to confirm a fusion of the PLCG1 and EYA2 genes. The fusion of the PLCG1 and EYA2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCG1-EYA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-RERE | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-REOR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-REGO | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-REGR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-OROR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GORE | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GROR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCG1-EYA2-20-AQAQ | 20 (40 μL) | 200 μL |
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EYA2 Gene Summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]
Gene Name: EYA Transcriptional Coactivator And Phosphatase 2
Chromosome: CHR20: 45523262 -45817492
Locus: 20q13.12
PLCG1 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase C Gamma 1
Chromosome: CHR20: 39766160 -39804357
Locus: 20q12
Gene Diseases
The PLCG1 EYA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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