PLCE1-SH3PXD2A Fusion FISH Probe
The PLCE1-SH3PXD2A Fusion FISH Probe is used to confirm a fusion of the PLCE1 and SH3PXD2A genes. The fusion of the PLCE1 and SH3PXD2A genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCE1-SH3PXD2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-RERE | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-REOR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-REGO | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-REGR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-OROR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GORE | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GROR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCE1-SH3PXD2A-20-AQAQ | 20 (40 μL) | 200 μL |
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SH3PXD2A Gene Summary
The SH3 And PX Domains 2A (SH3PXD2A) gene is located on chr10 :105353783-105615164 at 10q24.33.
Gene Name: SH3 And PX Domains 2A
Chromosome: CHR10: 105353783 -105615164
Locus: 10q24.33
PLCE1 Gene Summary
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase C Epsilon 1
Chromosome: CHR10: 95753745 -96088148
Locus: 10q23.33
Gene Diseases
The PLCE1 SH3PXD2A Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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