PLCB4-MACROD2 Fusion FISH Probe
The PLCB4-MACROD2 Fusion FISH Probe is used to confirm a fusion of the PLCB4 and MACROD2 genes. The fusion of the PLCB4 and MACROD2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCB4-MACROD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-RERE | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-REOR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-REGO | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-REGR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-OROR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GORE | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GROR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCB4-MACROD2-20-AQAQ | 20 (40 μL) | 200 μL |
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PLCB4 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Gene Name: Phospholipase C Beta 4
Chromosome: CHR20: 9049700 -9461462
Locus: 20p12.3-p12.2
MACROD2 Gene Summary
The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]
Gene Name: MACRO Domain Containing 2
Chromosome: CHR20: 13976145 -16033841
Locus: 20p12.1
Gene Diseases
The PLCB4 MACROD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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