PLCB4-BMP2 Fusion FISH Probe
The PLCB4-BMP2 Fusion FISH Probe is used to confirm a fusion of the PLCB4 and BMP2 genes. The fusion of the PLCB4 and BMP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCB4-BMP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-RERE | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-REOR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-REGO | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-REGR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-OROR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GORE | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GROR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCB4-BMP2-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP2 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 2
Chromosome: CHR20: 6748744 -6760910
Locus: 20p12.3
PLCB4 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Gene Name: Phospholipase C Beta 4
Chromosome: CHR20: 9049700 -9461462
Locus: 20p12.3-p12.2
Gene Diseases
The PLCB4 BMP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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