PLCB3-BAD Fusion FISH Probe
The PLCB3-BAD Fusion FISH Probe is used to confirm a fusion of the PLCB3 and BAD genes. The fusion of the PLCB3 and BAD genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCB3-BAD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-RERE | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-REOR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-REGO | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-REGR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-OROR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GORE | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GROR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCB3-BAD-20-AQAQ | 20 (40 μL) | 200 μL |
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BAD Gene Summary
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Name: BCL2 Associated Agonist Of Cell Death
Chromosome: CHR11: 64037299 -64052176
Locus: 11q13.1
PLCB3 Gene Summary
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Phospholipase C Beta 3
Chromosome: CHR11: 64018994 -64036924
Locus: 11q13.1
Gene Diseases
The PLCB3 BAD Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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