PLCB2-MAPKBP1 Fusion FISH Probe
The PLCB2-MAPKBP1 Fusion FISH Probe is used to confirm a fusion of the PLCB2 and MAPKBP1 genes. The fusion of the PLCB2 and MAPKBP1 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCB2-MAPKBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-RERE | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-REOR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-REGO | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-REGR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-OROR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GORE | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GROR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCB2-MAPKBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLCB2 Gene Summary
The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
Gene Name: Phospholipase C Beta 2
Chromosome: CHR15: 40580097 -40600174
Locus: 15q15.1
MAPKBP1 Gene Summary
This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]
Gene Name: Mitogen-activated Protein Kinase Binding Protein 1
Chromosome: CHR15: 42066631 -42120053
Locus: 15q15.1
Gene Diseases
The PLCB2 MAPKBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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